Cellular metabolic compound salvage

Across TCGA cell cohorts, RNA activity of the Cellular metabolic compound salvage pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GTF2F1, CLPP, and EEF2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular metabolic compound salvage activity versus GTF2F1 in BONE (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GTF2F1 →	+0.830	+2.130	<.001	.001	3	5
BONE	CLPP →	+0.992	+2.036	.001	.001	3	5
LIVER	EEF2 →	+1.070	+1.819	.001	<.001	3	5
BONE	LONP1 →	+1.259	+2.067	.002	.001	3	5
PANCREAS	RUVBL1 →	+0.684	+1.410	.008	<.001	3	5
LIVER	USP39 →	+0.854	+1.738	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043094 vs GTF2F1 — BONE

Explore this scatter interactively →