Penile erection

pathway activity — cross-omics
GO:0043084Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Penile erection pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLRX3, MTCO2P11, and AHR, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADGLRX3 →-0.422-0.633<.001<.00134
CCRCCMTCO2P11 →-1.190-0.248<.001<.00134
PDACAHR →-0.348-0.445.003.00833
CCRCCMACROH2A1 →-0.518-0.173.001.00833
PDACCAST →-0.444-0.615<.001<.00133
PDACRN7SKP292 →-0.435-0.555<.001.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration