Epigenetic programming of gene expression

Across TCGA patient cohorts, RNA activity of the Epigenetic programming of gene expression pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZMYM2, ADNP, and DHX9, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epigenetic programming of gene expression activity versus ZMYM2 in HNSC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZMYM2 →	+0.400	+0.087	<.001	<.001	3	7
HNSC	ADNP →	+0.472	+0.101	<.001	<.001	3	7
LSCC	DHX9 →	+0.259	+0.048	<.001	<.001	3	7
HNSC	FUS →	+0.457	+0.082	<.001	<.001	3	7
HNSC	GTF3C2 →	+0.303	+0.080	<.001	<.001	3	7
HNSC	NONO →	+0.238	+0.082	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043045 vs ZMYM2 — HNSC

Explore this scatter interactively →