Epigenetic programming of gene expression

Across TCGA patient cohorts, RNA activity of the Epigenetic programming of gene expression pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMELESS, TROAP, and FOXM1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epigenetic programming of gene expression activity versus TIMELESS in UCEC (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIMELESS →	+0.670	+0.576	.009	.001	3	7
LSCC	TROAP →	+0.949	+0.744	<.001	<.001	3	7
BRCA	FOXM1 →	+1.210	+0.392	<.001	<.001	3	6
BRCA	TTK →	+1.232	+0.477	<.001	<.001	3	6
GBM	HJURP →	+1.168	+0.532	<.001	.001	3	6
GBM	PKMYT1 →	+0.727	+0.383	.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043045 vs TIMELESS — UCEC

Explore this scatter interactively →