Epigenetic programming of gene expression

Across TCGA cell cohorts, RNA activity of the Epigenetic programming of gene expression pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOBP, BRD8, and DNAH6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epigenetic programming of gene expression activity versus SOBP in BLOOD_Leukemia (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SOBP →	+1.089	+0.158	.003	.007	3	4
LUNG_SCLC	BRD8 →	+0.780	+0.277	.001	.001	3	3
UPPER_AERODIGESTIVE_TRACT	DNAH6 →	-0.248	-0.261	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	TOM1L1 →	-0.709	-0.149	.001	.008	3	3
UPPER_AERODIGESTIVE_TRACT	ZNF345 →	+1.105	+0.179	.004	.001	3	3
BLOOD_Lymphoma	TIPRL →	-0.864	-0.172	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043045 vs SOBP — BLOOD_Leukemia

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