Positive regulation of macrophage activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of macrophage activation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMAP2, USP41, and JARID2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMAP2 grouped by Positive regulation of macrophage activation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SMAP2 →	+0.961	+0.171	.002	.006	3	5
LUNG_NSCLC_LUAD	USP41 →	-1.654	-0.149	.001	.002	3	4
STOMACH	JARID2 →	+1.306	+0.181	.002	.005	3	4
BLOOD_Lymphoma	KDM4B →	+1.002	+0.402	<.001	.003	3	4
BLOOD_Lymphoma	AMPD3 →	+1.862	+0.402	.003	.003	2	5
BLOOD_Lymphoma	TPCN2 →	+1.147	+0.402	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMAP2 by Positive regulation of macrophage activation activity — BONE

Explore this box plot interactively →