Positive regulation of macrophage activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of macrophage activation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NIP7, EXOSC6, and EBNA1BP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of macrophage activation activity versus NIP7 in LARGE_INTESTINE (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NIP7 →	+0.875	+0.249	.001	.005	3	7
OESOPHAGUS	EXOSC6 →	+0.905	+0.280	.003	<.001	3	6
LARGE_INTESTINE	EBNA1BP2 →	+0.728	+0.276	<.001	<.001	3	6
LARGE_INTESTINE	FCF1 →	+0.503	+0.256	.008	.003	3	5
LARGE_INTESTINE	CCDC138 →	+0.906	+0.190	.002	.009	3	5
SKIN	MICB →	+1.351	+0.189	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043032 vs NIP7 — LARGE_INTESTINE

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