Negative regulation of macrophage activation

Across TCGA patient cohorts, RNA activity of the Negative regulation of macrophage activation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PILRA, ARHGAP9, and LILRB3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of macrophage activation activity versus PILRA in LSCC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PILRA →	+0.616	+0.397	<.001	.002	3	10
HNSC	ARHGAP9 →	+0.979	+0.174	<.001	<.001	3	9
OV	LILRB3 →	+0.671	+0.331	<.001	.007	3	9
GBM	MYO1F →	+0.973	+0.362	<.001	<.001	3	9
LSCC	NCF1C →	+0.577	+0.394	<.001	<.001	3	9
UCEC	SIRPB1 →	+0.659	+0.603	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043031 vs PILRA — LSCC

Explore this scatter interactively →