Negative regulation of macrophage activation

Across TCGA cell cohorts, RNA activity of the Negative regulation of macrophage activation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDRG2, BIRC3, and SGK1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of macrophage activation activity versus NDRG2 in OESOPHAGUS (Pearson r = -0.94).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NDRG2 →	-2.764	-1.661	.003	.001	3	4
SKIN	BIRC3 →	+2.883	+2.194	<.001	<.001	3	4
BREAST	SGK1 →	+3.663	+1.253	<.001	.004	3	4
OVARY	CFAP61 →	-0.325	-1.292	.001	.004	3	3
OESOPHAGUS	TNS1 →	-2.266	-1.661	.002	.001	3	3
OESOPHAGUS	ZDHHC1 →	-1.930	-2.115	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043031 vs NDRG2 — OESOPHAGUS

Explore this scatter interactively →