Regulation of macrophage activation

Across TCGA patient cohorts, RNA activity of the Regulation of macrophage activation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL10, ARRB2, and PIK3R5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of macrophage activation activity versus IL10 in GBM (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IL10 →	+0.665	+0.227	.002	.008	3	8
GBM	ARRB2 →	+0.640	+0.264	<.001	.002	3	8
LSCC	PIK3R5 →	+0.661	+0.300	<.001	<.001	3	8
HNSC	SLA →	+0.739	+0.198	.002	<.001	3	8
OV	LCP2 →	+0.871	+0.110	<.001	<.001	3	8
GBM	CASS4 →	+0.847	+0.259	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043030 vs IL10 — GBM

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