Regulation of macrophage activation

Across TCGA cell cohorts, RNA activity of the Regulation of macrophage activation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF419, TRIM32, and SLC25A35, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF419 grouped by Regulation of macrophage activation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZNF419 →	+0.411	+0.129	.009	.008	3	5
OVARY	TRIM32 →	+0.698	+0.242	.007	<.001	3	4
OESOPHAGUS	SLC25A35 →	+1.066	+0.252	<.001	.005	3	4
OESOPHAGUS	MINK1 →	+1.403	+0.385	.001	<.001	3	4
OESOPHAGUS	SCD5 →	+1.325	+0.470	.002	<.001	3	4
OESOPHAGUS	FAM168A →	+1.108	+0.245	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF419 by Regulation of macrophage activation activity — CNS

Explore this box plot interactively →