T cell homeostasis

Across TCGA patient cohorts, RNA activity of the T cell homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLCB2, ADGRE2, and THEMIS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell homeostasis activity versus PLCB2 in HNSC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PLCB2 →	+0.679	+0.355	<.001	.001	3	6
CCRCC	ADGRE2 →	+0.419	+0.166	.006	.007	2	5
CCRCC	THEMIS2 →	+0.441	+0.212	.005	.008	3	4
CCRCC	PIK3R5 →	+0.473	+0.280	.001	.004	3	4
CCRCC	SLA →	+0.468	+0.254	.004	.002	3	4
UCEC	LGALS9 →	+0.569	+0.156	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043029 vs PLCB2 — HNSC

Explore this scatter interactively →