T cell homeostasis

Across TCGA cell cohorts, RNA activity of the T cell homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNX4, TARDBP, and PCBP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell homeostasis activity versus SNX4 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SNX4 →	+0.970	+0.579	<.001	.002	3	6
PANCREAS	TARDBP →	+0.456	+0.348	.004	.001	3	6
PANCREAS	PCBP1 →	+0.612	+0.470	.001	<.001	3	6
LUNG_NSCLC_LUSC	CCDC25 →	+1.144	+0.677	<.001	.007	3	5
PANCREAS	MCM2 →	+1.032	+0.272	.002	.001	3	5
BLOOD_Lymphoma	NFIC →	+1.652	+0.218	.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043029 vs SNX4 — UPPER_AERODIGESTIVE_TRACT

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