Myeloid dendritic cell differentiation

Across TCGA cell cohorts, RNA activity of the Myeloid dendritic cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM59, ATXN7L3B, and H4C4, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myeloid dendritic cell differentiation activity versus TRIM59 in BLOOD_Leukemia (Pearson r = -0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TRIM59 →	-1.658	-1.536	.003	.001	2	1
BLOOD_Leukemia	ATXN7L3B →	-0.240	-1.567	.004	.009	2	1
BLOOD_Leukemia	H4C4 →	-0.603	-1.536	.006	.001	2	1
BLOOD_Leukemia	LIG3 →	-1.165	-1.567	.006	.009	2	1
BLOOD_Leukemia	NDFIP2 →	-2.043	-1.536	.006	.001	2	1
BLOOD_Leukemia	THG1L →	-1.070	-1.536	.001	.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043011 vs TRIM59 — BLOOD_Leukemia

Explore this scatter interactively →