Golgi to plasma membrane protein transport

Across TCGA patient cohorts, RNA activity of the Golgi to plasma membrane protein transport pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS2, RPL5, and CLPX, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi to plasma membrane protein transport activity versus RPS2 in OV (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPS2 →	-0.393	-0.058	<.001	.004	3	8
GBM	RPL5 →	-0.210	-0.044	.002	.004	2	9
LSCC	CLPX →	-0.243	-0.040	.001	<.001	3	8
GBM	SEPTIN4_S432 →	+0.970	+0.053	<.001	<.001	3	8
UCEC	JPT1_S131 →	-0.494	-0.061	.001	<.001	3	8
OV	RPL10A →	-0.257	-0.049	.003	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043001 vs RPS2 — OV

Explore this scatter interactively →