Golgi to plasma membrane protein transport

Across TCGA cell cohorts, RNA activity of the Golgi to plasma membrane protein transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPM3, TMUB2, and TADA3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DPM3 grouped by Golgi to plasma membrane protein transport-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DPM3 →	+0.810	+0.698	.005	.005	3	4
URINARY_TRACT	TMUB2 →	-0.634	-0.425	.002	.002	3	3
BLOOD_Leukemia	TADA3 →	-1.529	-1.485	<.001	<.001	3	3
BLOOD_Leukemia	ARL16 →	+0.568	+1.088	.003	.004	2	4
SOFT_TISSUE	DHRS7B →	-0.589	-1.044	.006	.001	3	3
SOFT_TISSUE	RAB21 →	-0.681	-1.272	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DPM3 by Golgi to plasma membrane protein transport activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →