Golgi to plasma membrane protein transport

Across TCGA cell cohorts, RNA activity of the Golgi to plasma membrane protein transport pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT18, TSTD1, and C11orf80, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi to plasma membrane protein transport activity versus KRT18 in OVARY (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KRT18 →	+3.198	+0.313	.007	<.001	3	7
PANCREAS	TSTD1 →	+2.787	+0.267	.004	.002	3	6
BREAST	C11orf80 →	+0.970	+0.218	<.001	.003	3	6
OVARY	KRT8 →	+3.804	+0.305	.002	.003	3	6
BLOOD_Leukemia	BACH2 →	+2.229	+0.177	<.001	<.001	3	5
BLOOD_Myeloma	PIM1 →	+2.578	+0.428	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043001 vs KRT18 — OVARY

Explore this scatter interactively →