Regulation of Golgi to plasma membrane protein transport

Across TCGA patient cohorts, RNA activity of the Regulation of Golgi to plasma membrane protein transport pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNST, LINC00265, and C1orf220, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Golgi to plasma membrane protein transport activity versus CNST in CHOL (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	CNST →	+1.485	+0.115	<.001	<.001	3	27
ACC	LINC00265 →	+0.944	+0.057	<.001	<.001	3	26
UCS	C1orf220 →	+0.797	+0.061	<.001	<.001	3	26
UVM	C2CD5 →	+1.203	+0.059	<.001	<.001	3	25
UVM	LHX4 →	+0.538	+0.060	<.001	<.001	3	25
UVM	CLK1 →	+1.693	+0.061	<.001	<.001	3	25

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042996 vs CNST — CHOL

Explore this scatter interactively →