Regulation of Golgi to plasma membrane protein transport

Across TCGA cell cohorts, RNA activity of the Regulation of Golgi to plasma membrane protein transport pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RACK1, FAHD1, and RSC1A1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RACK1 grouped by Regulation of Golgi to plasma membrane protein transport-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RACK1 →	-0.415	-0.661	<.001	.003	3	10
LUNG_NSCLC_LUSC	FAHD1 →	-0.201	-0.444	.004	<.001	3	5
KIDNEY	RSC1A1 →	-0.425	-1.444	<.001	.001	3	5
BLOOD_Lymphoma	SAT1 →	-0.347	-0.382	.001	.006	3	4
LIVER	DPYSL2 →	+0.374	+1.558	<.001	.002	3	4
KIDNEY	MTMR9 →	-0.200	-1.012	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RACK1 by Regulation of Golgi to plasma membrane protein transport activity — BREAST

Explore this box plot interactively →