Regulation of Golgi to plasma membrane protein transport

Across TCGA cell cohorts, RNA activity of the Regulation of Golgi to plasma membrane protein transport pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BNIP1, LACTB, and DYSF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BNIP1 grouped by Regulation of Golgi to plasma membrane protein transport-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	BNIP1 →	-0.762	-1.620	.002	<.001	3	4
CNS	LACTB →	-1.191	-0.584	<.001	.007	3	3
CNS	DYSF →	-1.954	-0.663	<.001	.003	3	3
CNS	NABP1 →	-1.839	-0.767	<.001	.003	3	3
CNS	METRNL →	-1.816	-0.188	.005	.001	2	4
BLOOD_Leukemia	ZNF444 →	+0.622	+0.355	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BNIP1 by Regulation of Golgi to plasma membrane protein transport activity — KIDNEY

Explore this box plot interactively →