Regulation of Golgi to plasma membrane protein transport

Across TCGA cell cohorts, RNA activity of the Regulation of Golgi to plasma membrane protein transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2BC4, SRSF7, and PDS5A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Golgi to plasma membrane protein transport activity versus H2BC4 in BONE (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	H2BC4 →	-1.641	-0.272	.007	.009	3	6
STOMACH	SRSF7 →	+0.753	+0.294	.002	<.001	3	5
LIVER	PDS5A →	+0.918	+0.390	.005	.001	3	5
OESOPHAGUS	LYPLA1 →	+1.250	+0.242	<.001	.009	2	6
LUNG_NSCLC_LUAD	MRPL15 →	+0.797	+0.171	<.001	.002	3	5
BLOOD_Lymphoma	H2AC6 →	-2.656	-0.384	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042996 vs H2BC4 — BONE

Explore this scatter interactively →