Negative regulation of amyloid precursor protein biosynthetic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of amyloid precursor protein biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOMM40, C3orf86, and ACYP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of amyloid precursor protein biosynthetic process activity versus TOMM40 in LUAD (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOMM40 →	+0.360	+0.158	.002	.006	3	4
LUAD	C3orf86 →	-0.422	-0.301	.006	.001	3	3
PDAC	ACYP1 →	+0.261	+0.130	.005	.008	3	3
GBM	CCND2-AS1 →	-0.387	-0.533	<.001	<.001	3	3
COAD	TRAV8-2 →	-0.546	-0.611	.005	.007	3	3
CCRCC	RFK →	-0.458	-0.190	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042985 vs TOMM40 — LUAD

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