Negative regulation of amyloid precursor protein biosynthetic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of amyloid precursor protein biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM10, IVNS1ABP, and CYB561, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of amyloid precursor protein biosynthetic process activity versus ADAM10 in LARGE_INTESTINE (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADAM10 →	+1.477	+1.115	<.001	<.001	3	6
OVARY	IVNS1ABP →	+1.593	+1.462	.006	<.001	3	5
BLOOD_Lymphoma	CYB561 →	+4.420	+1.655	<.001	.009	3	5
OVARY	SPINT1 →	+4.284	+1.415	<.001	<.001	3	5
OVARY	C1orf116 →	+1.982	+1.425	.007	<.001	3	5
LARGE_INTESTINE	NPTN →	+0.905	+1.238	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042985 vs ADAM10 — LARGE_INTESTINE

Explore this scatter interactively →