Activation of Janus kinase activity

Across TCGA patient cohorts, RNA activity of the Activation of Janus kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIT1, PRKCB, and CD3D, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation of Janus kinase activity activity versus SIT1 in CCRCC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SIT1 →	+0.658	+0.215	.003	.003	3	5
LUAD	PRKCB →	+0.693	+0.467	<.001	.002	3	5
HNSC	CD3D →	+0.923	+0.245	.002	.003	3	5
CCRCC	GZMK →	+0.805	+0.329	.005	<.001	3	5
HNSC	CD3G →	+0.621	+0.274	.009	.004	2	6
CCRCC	CD3E →	+0.502	+0.323	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042976 vs SIT1 — CCRCC

Explore this scatter interactively →