Activation of Janus kinase activity

Across TCGA cell cohorts, RNA activity of the Activation of Janus kinase activity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5MC2, TMEM87B, and IGSF9B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP5MC2 grouped by Activation of Janus kinase activity-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ATP5MC2 →	+0.761	+1.326	.006	.004	3	4
LUNG_SCLC	TMEM87B →	-0.801	-1.145	.004	.001	3	4
STOMACH	IGSF9B →	-2.207	-1.026	.001	.003	2	5
UPPER_AERODIGESTIVE_TRACT	WARS2 →	+0.917	+1.310	<.001	.001	3	4
SKIN	FKBP14 →	-0.741	-1.167	.006	<.001	3	4
SKIN	DLX1 →	-1.004	-0.989	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP5MC2 by Activation of Janus kinase activity activity — LUNG_SCLC

Explore this box plot interactively →