D-amino acid transport

Across TCGA patient cohorts, RNA activity of the D-amino acid transport pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UTP25, WDR43, and ADNP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, D-amino acid transport activity versus UTP25 in COAD (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	UTP25 →	-0.370	-0.101	<.001	<.001	3	6
UCEC	WDR43 →	-0.216	-0.082	.001	.002	3	5
BRCA	ADNP →	-0.204	-0.075	.004	.009	3	5
PDAC	PRPF40A →	-0.146	-0.130	<.001	<.001	3	5
LSCC	DMXL1_S1285 →	+0.436	+0.107	<.001	.009	3	5
UCEC	IQGAP2 →	+0.550	+0.130	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042940 vs UTP25 — COAD

Explore this scatter interactively →