D-amino acid transport

Across TCGA patient cohorts, RNA activity of the D-amino acid transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AR, SPARCL1, and GALNT9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, D-amino acid transport activity versus AR in BRCA (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AR →	+1.892	+0.688	<.001	.001	3	4
GBM	SPARCL1 →	+0.678	+0.312	<.001	<.001	3	4
GBM	GALNT9 →	+0.667	+0.325	<.001	<.001	3	4
GBM	KCNQ3 →	+0.484	+0.272	.003	<.001	3	4
GBM	SLC1A3 →	+0.750	+0.309	<.001	<.001	3	4
GBM	RASAL1 →	+1.164	+0.280	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042940 vs AR — BRCA

Explore this scatter interactively →