Xenobiotic transport

Across TCGA patient cohorts, RNA activity of the Xenobiotic transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are JPT1, VRK1, and NCL_S67, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xenobiotic transport activity versus JPT1 in GBM (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	JPT1 →	-0.544	-0.044	.001	<.001	3	8
BRCA	VRK1 →	-0.422	-0.027	.001	.004	3	6
PDAC	NCL_S67 →	-0.600	-0.048	.002	<.001	3	6
GBM	TTC39A →	+0.610	+0.057	<.001	<.001	3	6
UCEC	CGNL1 →	+0.426	+0.051	.006	<.001	3	6
PDAC	CACYBP →	-0.160	-0.034	.007	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042908 vs JPT1 — GBM

Explore this scatter interactively →