Xenobiotic transport

Across TCGA cell cohorts, RNA activity of the Xenobiotic transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TICRR, GTPBP1, and ZNF397, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TICRR grouped by Xenobiotic transport-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TICRR →	+0.822	+0.990	<.001	.003	3	3
LUNG_NSCLC_LUSC	GTPBP1 →	+0.712	+1.588	.004	.002	3	3
BLOOD_Myeloma	ZNF397 →	+0.637	+1.403	.009	.003	3	3
URINARY_TRACT	ZFP37 →	+0.976	+1.231	<.001	.001	3	3
CNS	WNT9A →	+1.199	+1.029	<.001	.001	3	3
PANCREAS	SRSF4 →	-0.598	-0.893	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TICRR by Xenobiotic transport activity — BLOOD_Leukemia

Explore this box plot interactively →