Xenobiotic transport

Across TCGA cell cohorts, RNA activity of the Xenobiotic transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TICAM2, IL7R, and SH3KBP1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xenobiotic transport activity versus TICAM2 in BONE (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TICAM2 →	-1.626	-0.102	<.001	<.001	3	11
BONE	IL7R →	-2.555	-0.114	<.001	<.001	3	11
LUNG_NSCLC_LUSC	SH3KBP1 →	-2.932	-0.124	<.001	<.001	3	10
LUNG_NSCLC_LUSC	C11orf68 →	-1.990	-0.128	<.001	.001	3	10
BLOOD_Lymphoma	SYNE3 →	-1.072	-0.049	.001	.004	3	10
BONE	STK10 →	-1.921	-0.111	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042908 vs TICAM2 — BONE

Explore this scatter interactively →