Xenobiotic transport

Across TCGA cell cohorts, RNA activity of the Xenobiotic transport pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC2A1, REEP3, and MAGT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xenobiotic transport activity versus SLC2A1 in LARGE_INTESTINE (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC2A1 →	+2.734	+1.588	<.001	<.001	3	6
BREAST	REEP3 →	+0.593	+0.795	<.001	.001	3	6
BONE	MAGT1 →	+1.012	+1.503	.004	.001	3	5
LIVER	RAB22A →	+0.964	+1.441	.009	.003	2	6
KIDNEY	RASSF3 →	-0.831	-0.216	.007	.001	2	6
BONE	MRPL33 →	+1.207	+1.462	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042908 vs SLC2A1 — LARGE_INTESTINE

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