Vitamin B6 metabolic process

Across TCGA patient cohorts, RNA activity of the Vitamin B6 metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALPL, PNPO, and ALPL_S110, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin B6 metabolic process activity versus ALPL in OV (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ALPL →	+0.989	+0.091	.001	<.001	3	7
GBM	PNPO →	+0.340	+0.088	<.001	<.001	3	6
LSCC	ALPL_S110 →	+1.128	+0.083	<.001	<.001	3	6
BRCA	SLC2A5 →	+0.759	+0.123	<.001	<.001	3	5
LSCC	CDC37_S127 →	+0.244	+0.049	.008	.001	3	5
BRCA	DOCK8_S451 →	+0.418	+0.057	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042816 vs ALPL — OV

Explore this scatter interactively →