Vitamin B6 metabolic process

Across TCGA cell cohorts, RNA activity of the Vitamin B6 metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BMP8B, AKAP5, and RTN4R, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BMP8B grouped by Vitamin B6 metabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	BMP8B →	-1.315	-1.297	.003	.005	3	3
OVARY	AKAP5 →	-0.835	-0.839	.001	<.001	3	3
PANCREAS	RTN4R →	+1.340	+1.132	<.001	.008	3	3
LUNG_NSCLC_LUAD	TUFT1 →	-1.047	-0.697	.001	.003	3	3
LUNG_NSCLC_LUAD	RAP2B →	+0.905	+0.749	.004	.006	3	3
LARGE_INTESTINE	TBC1D19 →	+1.153	+1.399	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BMP8B by Vitamin B6 metabolic process activity — KIDNEY

Explore this box plot interactively →