Vitamin B6 metabolic process

Across TCGA cell cohorts, RNA activity of the Vitamin B6 metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD1, RASSF3, and LONP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin B6 metabolic process activity versus ANKRD1 in STOMACH (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ANKRD1 →	-3.882	-1.312	<.001	<.001	3	5
BREAST	RASSF3 →	+0.880	+0.483	<.001	.008	3	5
STOMACH	LONP1 →	+0.828	+1.217	.004	.001	3	4
LUNG_NSCLC_LUSC	IGFBP6 →	-4.370	-1.644	.006	<.001	3	4
SKIN	SNX25 →	+0.618	+0.854	.006	.007	3	4
PANCREAS	FN3K →	+0.781	+0.999	.004	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042816 vs ANKRD1 — STOMACH

Explore this scatter interactively →