snRNA transcription by RNA polymerase III

Across TCGA patient cohorts, RNA activity of the snRNA transcription by RNA polymerase III pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC150, KIF18B, and HASPIN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA transcription by RNA polymerase III activity versus CCDC150 in UCEC (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCDC150 →	+0.670	+0.290	<.001	.001	3	7
UCEC	KIF18B →	+0.965	+0.324	<.001	.009	3	7
UCEC	HASPIN →	+0.691	+0.316	<.001	.009	3	6
GBM	HROB →	+0.665	+0.308	<.001	<.001	3	6
UCEC	TROAP →	+0.954	+0.334	.001	.007	3	6
UCEC	ESPL1 →	+1.178	+0.393	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042796 vs CCDC150 — UCEC

Explore this scatter interactively →