snRNA transcription by RNA polymerase III

Across TCGA cell cohorts, RNA activity of the snRNA transcription by RNA polymerase III pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FKBP3, PLAGL2, and RAB11FIP3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FKBP3 grouped by snRNA transcription by RNA polymerase III-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FKBP3 →	-0.228	-0.509	.001	.009	3	3
BLOOD_Leukemia	PLAGL2 →	-0.186	-0.512	<.001	.001	3	3
LUNG_NSCLC_LUAD	RAB11FIP3 →	-0.210	-1.492	.001	.001	3	2
BLOOD_Leukemia	NR1D2 →	+0.250	+0.667	.001	.002	3	2
BLOOD_Leukemia	RCSD1 →	+0.315	+0.577	<.001	<.001	3	2
BLOOD_Leukemia	GABRA1 →	-0.292	-0.520	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FKBP3 by snRNA transcription by RNA polymerase III activity — BLOOD_Leukemia

Explore this box plot interactively →