snRNA transcription by RNA polymerase III

Across TCGA cell cohorts, RNA activity of the snRNA transcription by RNA polymerase III pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGA1, EXOSC4, and DRAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA transcription by RNA polymerase III activity versus HMGA1 in LUNG_SCLC (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HMGA1 →	+1.042	+0.421	.002	<.001	3	5
BREAST	EXOSC4 →	-1.529	-0.811	.008	.004	3	4
LARGE_INTESTINE	DRAP1 →	+1.344	+1.285	<.001	<.001	3	3
LUNG_SCLC	ZNF263 →	-0.716	-0.581	<.001	<.001	3	3
LUNG_NSCLC_LUAD	SNRNP27 →	+0.658	+1.547	.008	.003	3	3
BREAST	ZNF696 →	-1.477	-0.848	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042796 vs HMGA1 — LUNG_SCLC

Explore this scatter interactively →