snRNA transcription by RNA polymerase II

Across TCGA cell cohorts, RNA activity of the snRNA transcription by RNA polymerase II pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELL2, ELL, and NBEA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ELL2 grouped by snRNA transcription by RNA polymerase II-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ELL2 →	-0.333	-0.367	.001	.008	3	8
BREAST	ELL →	-0.327	-0.244	.001	.002	3	7
OESOPHAGUS	NBEA →	-0.251	-0.510	<.001	<.001	3	5
LUNG_NSCLC_LUSC	MAP4K4 →	-0.486	-0.310	.005	.001	3	4
PANCREAS	PEX13 →	-0.218	-0.271	.005	.004	3	4
PANCREAS	CRLF3 →	+0.324	+0.437	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ELL2 by snRNA transcription by RNA polymerase II activity — OVARY

Explore this box plot interactively →