snRNA transcription by RNA polymerase II

Across TCGA cell cohorts, RNA activity of the snRNA transcription by RNA polymerase II pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP2C8, RMND5A, and PCBP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP2C8 grouped by snRNA transcription by RNA polymerase II-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CYP2C8 →	+0.288	+0.090	.002	.004	3	5
UPPER_AERODIGESTIVE_TRACT	RMND5A →	+0.204	+0.102	.004	<.001	3	4
LUNG_NSCLC_LUAD	PCBP4 →	+0.089	+0.050	.006	.006	3	4
BONE	NKAIN4 →	-0.265	-0.106	.001	<.001	3	4
CNS	PDLIM4 →	-0.257	-0.055	.003	.001	3	4
LUNG_SCLC	RASSF7 →	+0.240	+0.090	.006	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP2C8 by snRNA transcription by RNA polymerase II activity — LIVER

Explore this box plot interactively →