snRNA transcription by RNA polymerase II

Across TCGA cell cohorts, RNA activity of the snRNA transcription by RNA polymerase II pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELL, UTP15, and EIF3G, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA transcription by RNA polymerase II activity versus ELL in BONE (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ELL →	+0.853	+0.112	<.001	<.001	3	15
BLOOD_Lymphoma	UTP15 →	+0.672	+0.063	<.001	<.001	3	12
LUNG_NSCLC_LUSC	EIF3G →	+0.656	+0.080	.005	.004	3	10
BLOOD_Lymphoma	ENTR1 →	+0.951	+0.079	<.001	<.001	3	10
PANCREAS	DAPK3 →	+0.884	+0.095	<.001	.003	3	10
BLOOD_Lymphoma	IPO4 →	+1.551	+0.088	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042795 vs ELL — BONE

Explore this scatter interactively →