snRNA transcription by RNA polymerase II

Across TCGA cell cohorts, RNA activity of the snRNA transcription by RNA polymerase II pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGA1, FOSL1, and UBE2G2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA transcription by RNA polymerase II activity versus HMGA1 in BREAST (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	HMGA1 →	+2.419	+0.892	<.001	.001	3	6
SKIN	FOSL1 →	+2.493	+1.025	<.001	.004	3	3
BREAST	UBE2G2 →	-1.081	-0.628	.008	.004	2	4
SKIN	FGF1 →	+1.867	+1.495	.009	.009	3	3
BLOOD_Leukemia	UBIAD1 →	-0.384	-0.442	.008	.001	3	3
BLOOD_Myeloma	NANOS3 →	-1.463	-0.446	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042795 vs HMGA1 — BREAST

Explore this scatter interactively →