5S class rRNA transcription by RNA polymerase III

Across TCGA patient cohorts, RNA activity of the 5S class rRNA transcription by RNA polymerase III pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF22, DHRS13, and SAPCD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 5S class rRNA transcription by RNA polymerase III activity versus KIF22 in GBM (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KIF22 →	+0.441	+0.176	.001	.002	3	5
BRCA	DHRS13 →	+0.743	+0.549	<.001	.002	3	5
GBM	SAPCD2 →	+0.653	+0.189	.003	<.001	3	5
COAD	OLR1 →	-1.460	-0.191	<.001	.002	3	4
LSCC	CEP76 →	+0.410	+0.172	.009	.001	3	4
LSCC	FARS2 →	+0.289	+0.159	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042791 vs KIF22 — GBM

Explore this scatter interactively →