Nucleolar large rRNA transcription by RNA polymerase I

Across TCGA patient cohorts, RNA activity of the Nucleolar large rRNA transcription by RNA polymerase I pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CHD4, CTNNBL1, and MBD3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleolar large rRNA transcription by RNA polymerase I activity versus CHD4 in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CHD4 →	+0.243	+0.038	<.001	<.001	3	7
BRCA	CTNNBL1 →	+0.230	+0.039	<.001	<.001	3	7
BRCA	MBD3 →	+0.469	+0.039	<.001	<.001	3	7
BRCA	SMARCA5 →	+0.295	+0.036	<.001	<.001	3	6
LSCC	WDR5 →	+0.236	+0.055	<.001	<.001	3	6
LSCC	ZMYM3_S464 →	+0.411	+0.046	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042790 vs CHD4 — BRCA

Explore this scatter interactively →