Nucleolar large rRNA transcription by RNA polymerase I

Across TCGA patient cohorts, RNA activity of the Nucleolar large rRNA transcription by RNA polymerase I pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDIAS, MTFR2, and EXO1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleolar large rRNA transcription by RNA polymerase I activity versus DDIAS in GBM (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DDIAS →	+0.881	+0.349	<.001	<.001	3	8
BRCA	MTFR2 →	+0.749	+0.327	.005	<.001	3	8
GBM	EXO1 →	+1.183	+0.317	<.001	<.001	3	7
LUAD	CENPI →	+0.750	+0.377	.002	.003	3	7
GBM	TTK →	+1.156	+0.322	<.001	<.001	3	7
LSCC	FAM72B →	+0.392	+0.168	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042790 vs DDIAS — GBM

Explore this scatter interactively →