Nucleolar large rRNA transcription by RNA polymerase I

Across TCGA cell cohorts, RNA activity of the Nucleolar large rRNA transcription by RNA polymerase I pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDK7, ACTL6A, and MRPL53, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDK7 grouped by Nucleolar large rRNA transcription by RNA polymerase I-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CDK7 →	+0.946	+0.271	.008	.006	3	4
LUNG_NSCLC_LUSC	ACTL6A →	-0.908	-0.248	.004	.005	3	3
BREAST	MRPL53 →	-0.698	-0.106	.007	.007	2	4
SOFT_TISSUE	SSBP3 →	+1.038	+0.373	.002	.001	3	3
CNS	SUSD1 →	-0.989	-0.193	<.001	.003	3	3
KIDNEY	C16orf71 →	-0.535	-0.282	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDK7 by Nucleolar large rRNA transcription by RNA polymerase I activity — STOMACH

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