Nucleolar large rRNA transcription by RNA polymerase I

Across TCGA cell cohorts, RNA activity of the Nucleolar large rRNA transcription by RNA polymerase I pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLB1, REEP3, and CAMK2N1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleolar large rRNA transcription by RNA polymerase I activity versus GLB1 in BLOOD_Lymphoma (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GLB1 →	-0.888	-0.141	.001	.003	3	5
PANCREAS	REEP3 →	-1.375	-0.352	<.001	.001	3	5
BREAST	CAMK2N1 →	-2.108	-0.544	<.001	.008	2	5
SKIN	TAF4B →	+0.779	+0.294	.001	.004	3	4
SKIN	SLC6A15 →	+1.266	+0.255	.006	.002	3	4
STOMACH	LAMTOR3 →	-1.025	-0.405	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042790 vs GLB1 — BLOOD_Lymphoma

Explore this scatter interactively →