tRNA 3'-end processing

Across TCGA patient cohorts, RNA activity of the tRNA 3'-end processing pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRNT1, CHCHD4, and PTGFRN, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA 3'-end processing activity versus TRNT1 in OV (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TRNT1 →	+0.346	+0.052	<.001	<.001	3	9
BRCA	CHCHD4 →	+0.402	+0.033	.002	.009	3	5
LSCC	PTGFRN →	-0.479	-0.051	<.001	.001	3	5
UCEC	COA7 →	+0.301	+0.062	<.001	<.001	3	5
PDAC	OXSR1 →	+0.312	+0.053	<.001	<.001	3	4
BRCA	CBX4_S291 →	+0.556	+0.033	.007	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042780 vs TRNT1 — OV

Explore this scatter interactively →