tRNA 3'-end processing

Across TCGA patient cohorts, RNA activity of the tRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EFEMP2, MT2A, and OLFML3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA 3'-end processing activity versus EFEMP2 in PDAC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	EFEMP2 →	-0.315	-0.092	.001	.002	3	5
OV	MT2A →	-0.916	-0.146	<.001	<.001	3	4
BRCA	OLFML3 →	-0.966	-0.129	<.001	.003	3	4
BRCA	CD63 →	-0.439	-0.186	<.001	<.001	3	4
BRCA	HTRA1 →	-0.923	-0.141	.004	.004	3	4
BRCA	COPZ2 →	-0.673	-0.125	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042780 vs EFEMP2 — PDAC

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