tRNA 3'-end processing

Across TCGA cell cohorts, RNA activity of the tRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF579, AGPAT4, and GLO1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF579 grouped by tRNA 3'-end processing-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZNF579 →	-0.680	-0.245	.004	.001	3	4
BREAST	AGPAT4 →	-0.896	-0.318	.001	.008	3	3
LARGE_INTESTINE	GLO1 →	+0.956	+0.215	<.001	<.001	3	3
LARGE_INTESTINE	ALOX5AP →	-0.628	-0.200	.004	<.001	3	3
LARGE_INTESTINE	RABGGTB →	+1.245	+0.236	<.001	<.001	2	4
LARGE_INTESTINE	CHEK2 →	+0.928	+0.202	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF579 by tRNA 3'-end processing activity — OESOPHAGUS

Explore this box plot interactively →