tRNA 3'-end processing

Across TCGA cell cohorts, RNA activity of the tRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEDD9, KCNMB3, and SLC37A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA 3'-end processing activity versus NEDD9 in LIVER (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NEDD9 →	-2.671	-0.241	.008	<.001	3	5
LIVER	KCNMB3 →	+1.145	+0.229	<.001	<.001	3	5
LIVER	SLC37A2 →	-3.016	-0.221	<.001	<.001	3	4
LIVER	ILF2 →	+0.625	+0.228	.001	<.001	3	4
PANCREAS	CHTOP →	+0.635	+0.145	.005	.003	3	4
LIVER	NR1D2 →	-0.905	-0.195	.002	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0042780 vs NEDD9 — LIVER

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